Figure 4.

Relations between aortic modulus of elasticity and in vivo stiffness [pulse wave velocity (PWV)] and select inflammatory markers that were higher with aging. In male and female, young (6–7 mo) and old (27–29 mo) C57BL/6N mice, relations between aortic modulus of elasticity and plasma levels of interferon-γ (IFN-γ; A), interleukin-6 (IL-6; B), and monocyte chemoattractant protein-1 (MCP-1; C) and between aortic stiffness and plasma levels of IFN-γ (D), IL-6 (E), and MCP-1 (F); n = 10–14/group. Plasma was analyzed by cytokine array and reported as arbitrary units (AU) of intensity. All cytokines/chemokines were log-transformed to account for skewness (Shapiro–Wilk normality test; all P < 0.05). Statistics are simple linear regression.