Figure 7.

Expression of synaptic proteins is upregulated in transplanted photoreceptors

(A) Heatmaps of synaptic gene expression in transplanted and cultured retinal organoids.

(B) IHC test showed CtBP2⁺ ribbons synapse in photoreceptors in transplanted (n = 4 eyes) than cultured retinal organoids (n = 4 in one batch). CtBP2⁺ pre-synapses are highlighted with white dots using Imaris (version 9.1), raw images are on the right panel. IHC staining of SCGN (green) showed the recipient bipolar layer.

Statistical data were presented as mean ± SD.