Table 2.
Correspondence Between Concepts Measured by Generic Patient-Reported Outcome Instruments of Health-Related Quality of Life and Areas Impacted by AL Amyloidosis
| SF-36v2 Health Survey | PROMIS Global Health Scale | PROMIS-29 Profile | |
|---|---|---|---|
| General Health | x | x | |
| Physical Functioning and Daily Activities | |||
| Activities of daily living | x | x | |
| Household activities/chores | x | x | |
| Physical functioning/mobility | x | x | x |
| Reduction in physical strength | |||
| Difficulty walking | x | x | |
| Leisure activities/exercise/hobbies | x | x | |
| Work limitations | x | x | |
| Social Functioning | |||
| Social functioning | x | x | x |
| Burden on family | |||
| Family roles | x | ||
| Difficulty sustaining social interaction with family | x | x | |
| Negative impacts on relationship with spouse | |||
| Travel | |||
| Emotional Well-Being | |||
| Mental/emotional health | x | x | x |
| Nervousness/anxiety | x | x | |
| Sadness/depression | x | x | |
| Worry | x | ||
| Fear | x | ||
| Anger | |||
| Frustration | |||
| Increased stress | |||
| Difficulty accepting and coping | |||
| Decreased motivation | |||
| Decreased attractiveness | |||
| Poor self-esteem | |||
| Cognition | |||
| Other Impacts | |||
| Loss of balance | |||
| Sleep (disruption/need more) | x | ||
| Appetite/food restrictions | |||
| Altered taste in food | |||
| Symptoms Often Evaluated in HRQOL PRO Instruments | |||
| Pain | x | x | x |
| Fatigue | x | x | x |