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. 2022 Oct 26;72(2):164–172. doi: 10.1538/expanim.22-0104

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©2023 Japanese Association for Laboratory Animal Science

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)

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Fig. 1. — The expression levels of IRG1 and itaconate were increased in WT mice. (A, B) The expression levels of IRG1 in the control group and LPS group were analyzed by Western blot. (C) The levels of itaconate in lung tissue of the control group and LPS group were detected by UPLC-MS/MS. **P<0.01, ****P<0.0001. LPS, lipopolysaccharide; ALI, acute lung injury; IRG1, aconitate decarboxylase; WT, wild type; UPLC-MS/MS, ultrahigh-performance liquid chromatography-tandem mass spectroscopy.