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. 2022 Oct 26;72(2):164–172. doi: 10.1538/expanim.22-0104

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©2023 Japanese Association for Laboratory Animal Science

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Fig. 3. — 4-OI relieved histological changes and alveolar exudation in WT mice. (A) The physical appearance of the mice was evaluated by assessment scores. (B, C) The plasma levels of IL-6 and TNF-α were determined by ELISA. (D, E) The histological score was determined by hematoxylin and eosin staining (400×). (F) Comparison of protein concentration in BALF. (G) Comparison of Evans Blue leakage in lung tissue. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001. 4-OI, 4-octyl itaconate; LPS, lipopolysaccharide; WT, wild type; IL-6, interleukin 6; TNF-α, tumor necrosis factor-alpha; ELISA, enzyme-linked immunosorbent assay; BALF, bronchoalveolar lavage fluid.