Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic illustration of the anti-inflammatory effects of itaconate mediated by autophagy in the modulation of ALI. Lipopolysaccharide promotes endogenous itaconate through the activation of Irg1. Itaconate assists in the dissociation of KEAP1 and NRF2, and NRF2 thereby inhibits autophagic genes such as P62 and LC3 to downregulate inflammation.
