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. 2023 Mar 17;72(6):781–794. doi: 10.2337/db22-0619

Figure 4.

Figure 4

Gene expression levels of proinflammatory cytokines, receptors, proteases, and adhesion molecules. mRNA expression levels of multiple genes from cytokines and cytokine receptors (A) [IL-1α (a), Ang2 (b), CCL2 (c), CCL5 (d), CCL7 (e), CCR2 (f), and CCR5 (g)], proteases (B) [cathepsin (Cts) B (h), Cts K (i), Cts L (j), Cts S (k), MMP2 (l), and MMP12 (m)], and adhesion molecules (C) [ICAM1 (n) and VCAM1 (o)] were statistically compared between the different treatment groups: 1) control versus CXCL1 IVT, 2) CXCL1 IVT versus Ly6G, and 3) CXCL1 IVT versus Ly6G + CXCL1 IVT. Data are presented as mean ± SD. *P < 0.05, ***P < 0.001, ****P < 0.0001.