Extended Data Fig. 5. Response to third dose booster vaccination in severe obesity.
a, Anti-RBD (Receptor Binding Domain) IgG levels (MFI, mean fluorescence intensity) were higher in people with severe obesity (magenta, n = 25) compared to individuals with normal BMI (black, n = 16) (**P = 0.0013 in Mann-Whitney U test). Each symbol represents an individual person studied at Day 28; line indicates the median. b, Neutralizing antibody titres (NT50) against the Omicron variant of SARS-CoV-2 were markedly reduced compared with wild type virus (Day 28), but no difference was observed between groups (severe obesity (magenta, n = 15) compared to normal BMI controls (n = 25, black)). Each symbol represents an individual person, horizontal bar indicates the median and interquartile range and p-values are from a Mann-Whitney U test. ns, not significant.