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. 2023 Apr 14;29(5):1103–1112. doi: 10.1038/s41591-023-02321-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — Efficacy evaluable population; Primary and expansion cohorts; (A) Investigator assessment (B) Independent radiology assessment. ATC: Among 20 responders by investigator assessment, nine (45%) patients had disease progression and four (20%) died. Seven (35%) patients ended their follow-up and were censored. Among 19 responders by independent radiology assessment, 12 (63%) patients had disease progression and one (5%) died. Six (32%) patients ended their follow-up and were censored. BTC: Among 23 responders by investigator assessment, 20 (87%) patients had disease progression and 2 (9%) died. One (4%) patient was censored due to end of follow-up. Among the 20 responders by independent radiology assessment, 14 (70%) patients had disease progression and one (5%) died. Five (25%) patients were censored due to end of follow-up. LGG: Among nine responders by investigator assessment, two (22%) patients had disease progression. Seven (78%) patients were censored due to end of follow-up. Among eight responders by independent radiology assessment, seven (88%) patients had disease progression. One (13%) patient was censored due to end of follow-up. HGG: Among 15 responders by investigator assessment, nine (60%) patients had disease progression. Six (40%) patients were censored due to end of follow-up. Among 14 responders by independent radiology assessment, 12 (86%) patients had disease progression. Two (14%) patients were censored due to end of follow-up. ASI: Due to small numbers of responders, KM curves are not shown. Of the two responders by investigator assessment, one patient had disease progression and one was censored due to end of follow-up. Among the two responders by independent radiology assessment, both patients had disease progression. HCL: Among 49 responders by investigator assessment, four (8%) patients had disease progression and two (4%) patients died. Forty-three patients (88%) were censored due to end of follow-up. MM: Due to small numbers of responders, KM curves are not shown. Among five responders by investigator assessment, 4 (80%) patients had disease progression. One (20%) patient was censored due to end of follow-up. ASI, adenocarcinoma of small intestine; ATC, anaplastic thyroid cancer; BTC, biliary tract cancer; G, grade; HCL, hairy cell leukemia; HGG, high (WHO G3/G4) grade glioma; KM, Kaplan-Meier; LGG, low (WHO G1/G2) grade glioma; MM, multiple myeloma; WHO, World Health Organization.