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. 2023 May 15;29(5):1243–1252. doi: 10.1038/s41591-023-02318-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — This analysis confirmed that compared to other PSEN1 E280A carriers who developed MCI at younger ages, the RELN-COLBOS carrier had relatively spared tau pathology in the medial temporal lobe (entorhinal cortex / parahippocampal gyrus), but not in other areas including temporal neocortex (inferior temporal). a-c, Regional tau PET signal (Flortaucipir, FTP) standardized uptake value ratio (SUVr) in three regions of interest: entorhinal (EC, a), inferior temporal (IT, b), and precuneus (PC, C). d-f, Ratios of tau PET uptake in medial temporal (EC) and neocortical (IT, PC) regions. d, EC:IT ratio, e, EC:PC ratio, f, ratio of EC to average of IT and PC (neocortical average). The tau pattern of the RELN-COLBOS patient was notable for the relative involvement of medial temporal versus temporal neocortex, particularly given the older age of the RELN-COLBOS patient compared to other carriers.