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. 2023 May 19;29(5):1273–1286. doi: 10.1038/s41591-023-02324-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — a, SparCC co-occurrence network using centered log-ratio transformed OTUs in the AC-ICAM246 tumor samples. b, Overlay of network taxa with taxa enriched in ICR High or Low group (left panel), with taxa enriched in tumor vs normal colon samples (middle panel), and when present in the MBR classifier, either as low or high risk (right panel). c, Association between OS and PFS and the sum of the relative abundance of each genus (High vs low based on median) in each cluster in AC-ICAM246. d, Association between OS and PFS and distinct alpha diversity metrics (High vs low based on median) of the tumor microbiome in AC-ICAM246. HR (center), corresponding 95% confidence intervals (error bars) and corresponding P values are calculated by cox proportional hazard regression (c-d). All P values are two-sided; n reflects the independent number of samples in all panels. Overall Survival (OS). Progression-Free Survival (PFS).