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. 2023 May 19;29(5):1273–1286. doi: 10.1038/s41591-023-02324-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — Pairwise Pearson correlation matrix of the 103 immune traits. Seven clusters of highly correlated immune traits were defined as Immune Modules: Myeloid signatures (M1), lymphocyte infiltration signatures (M2), IFN response and immune checkpoints (M3), HLA-antigen presentation signatures (M4), TGF-β response and myeloid signatures (M5), wound healing and proliferation-related immune traits (M6) and three separately clustered signatures (M7). Top annotation displays the Immune traits with their respective Immune module (M1-M7), Immune Trait Module and corresponding immune trait categories (as described in Sayaman et al, 2021).