Table 2.

Serum HtrA4 levels and UtA-PI in overall, early-onset, and late-onset preeclampsia compared with control healthy women.

	Control (n = 332)	Preeclampsia (n = 34)	Early-onset preeclampsia (n = 6)	Late-onset preeclampsia (n = 28)	p value
HtrA4 (ng/ml)	4.6 ± 2.2	9.4 ± 3.9			< 0.001
			11.3 ± 3.8		< 0.001
				9.0 ± 3.8	< 0.001
Median of HtrA4 (ng/ml)	4.1 (3.0, 5.7)	9.0 (7.1, 10.3)			< 0.001
			10.3 (8.7, 12.7)		< 0.001
				8.7 (5.7, 10)	< 0.001
UtA-PI	1.7 ± 0.5	1.8 ± 0.6			0.435
			2.3 ± 0.5		0.002
				1.6 ± 0.6	0.607
Any notching	210 (63.3)	28 (82.4)			0.026
			6 (100)		0.091
				22 (78.6)	0.103
Bilateral notching	150 (45.2)	25 (73.5)			0.002
			6 (100)		0.009
				19 (67.9)	0.02

Data are presented in median (interquartile range), mean ± standard deviation or n (%).

HtrA4 high-temperature requirement factor A4, UtA-PI uterine artery pulsatility index.