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. 2023 May 22;13:8272. doi: 10.1038/s41598-023-34929-8

Table 5.

Cox proportional hazards analysis for the independent risk factors in respiratory disease mortality.

Hazard ratio 95% CI p value
Respiratory diseases including malignant neoplasm (n = 1263)
 Sex (men) 3.750 3.056 4.623  < 0.0001*
 Age (+ 1 year) 1.106 1.090 1.122  < 0.0001*
 Body mass index (+ 1 kg/m2) 0.915 0.892 0.939  < 0.0001*
 Systolic blood pressure (+ 1 mmHg) 0.995 0.995 1.004 0.6863
 Habit of walking and/or physical activity 0.839 0.718 0.979 0.0261*
 Fast walking speed 0.518 0.439 0.610  < 0.0001*
 Smoking history 1.941 1.627 2.309  < 0.0001*
 Drinking habits 0.617 0.523 0.729  < 0.0001*
 Adequate sleep 1.170 0.965 1.430 0.1114
 History of cerebrovascular diseases 1.623 1.247 2.079 0.0005*
 History of cardiovascular diseases 1.273 0.991 1.613 0.0588
 Hemoglobin A1c (+ 1%) 1.213 1.127 1.298  < 0.0001*
 Low density lipoprotein cholesterol (+ 1 mg/dl) 0.995 0.992 0.997  < 0.0001*
 Alanine aminotransferase (+ 1 U/L) 1.001 0.997 1.005 0.5408
 Uric acid (+ 1 mg/dl) 1.056 1.012 1.084 0.0161*
 Creatinine (+ 1 mg/dl) 1.132 0.902 1.308 0.2430
 Urinary protein (positive) 1.432 1.189 1.716 0.0002*
Respiratory diseases excluding malignannt neoplasm (n = 437)
 Sex (men) 3.898 2.879 5.355  < 0.0001*
 Age (+ 1 year) 1.141 1.111 1.173  < 0.0001*
 Body mass index (+ 1 kg/m2) 0.831 0.790 0.874  < 0.0001*
 Diastolic blood pressure (+ 1 mmHg) 0.989 0.977 1.001 0.0703
 Weight gain more than 10 kg since age 20 1.083 0.767 1.515 0.6470
 Exercise habit for more than 30 min 0.591 0.442 0.783 0.0002*
 Fast walking speed 0.274 0.197 0.375  < 0.0001*
 History of cerebrovascular diseases 2.049 1.379 2.950 0.0006*
 History of cardiovascular diseases 1.336 0.893 1.936 0.1537
 History of chronic renal failure 2.175 0.765 4.831 0.1309
 Hemoglobin A1c (+ 1%) 1.241 1.108 1.366 0.0005*
 Low density lipoprotein cholesterol (+ 1 mg/dl) 0.995 0.991 0.999 0.0281*
 Aspartate aminotransferase (+ 1 U/L) 1.002 0.996 1.005 0.3752
 Uric acid (+ 1 mg/dl) 1.066 1.000 1.101 0.0497*
 Estimated glomerular filtration rate (+ 1 mL/min/1.73m2) 1.006 1.003 1.007 0.0003*
 Urinary protein (positive) 1.876 1.396 2.491  < 0.0001*
Malignant neoplasm of respiratory tract (n = 826)
 Sex (men) 3.607 2.306 5.723  < 0.0001*
 Age (+ 1 year) 1.096 1.064 1.131  < 0.0001*
 Waist circumference (+ 1 cm) 1.014 0.996 1.032 0.1242
 Systolic blood pressure (+ 1 mmHg) 0.999 0.989 1.008 0.7573
 Fast walking speed 0.629 0.456 0.860 0.0035*
 Smoking history 3.287 2.349 4.586  < 0.0001*
 Drinking habits 0.842 0.601 1.187 0.3247
 Adequate sleep 1.187 0.806 1.810 0.3955
 History of cerebrovascular diseases 1.650 0.955 2.671 0.0711
 History of cardiovascular diseases 0.717 0.375 1.244 0.2507
 Hemoglobin A1c (+ 1%) 1.209 1.035 1.380 0.0188*
 Low density lipoprotein cholesterol (+ 1 mg/dl) 0.996 0.991 1.002 0.1794
 Alanine aminotransferase (+ 1 U/L) 1.000 0.988 1.006 0.9749
 Hemoglobin (+ 1 g/dl) 0.884 0.792 0.993 0.0376*
 Uric acid (+ 1 mg/dl) 1.011 0.897 1.091 0.8525
 Creatinine (+ 1 mg/dl) 1.068 0.537 1.475 0.8094
 Urinary protein (positive) 0.964 0.634 1.421 0.8583

Asterisk means p < 0.05, statistically significant.