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. 2023 May 2;70(4):713–723. doi: 10.1007/s12630-023-02415-4

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 2 — Altered pharmacokinetics in ICU patients receiving prolonged continuous infusions of sedatives and analgesics. Figure is reproduced with permission from Tse AH, Ling L, Lee A, Joynt GM. Altered pharmacokinetics in prolonged infusions of sedatives and analgesics among adult critically ill patients: a systematic review. Clin Ther 2018; 40: 1598–615 (Elsevier; license number 5330910863857).

Cl = clearance; T_1/2 = half-life; V_dss = volume of distribution at steady state