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. 2023 May 12;40(3):277–294. doi: 10.1007/s10719-023-10120-z

Fig. 2.

Fig. 2

Working model of the proposed impact of polySia and polysialylated proteins on microglia activation and recruitment. See text for details. Abbreviations: CCL, C-C motif ligand; CCR, C-C motif chemokine receptor; CXCR C-X-C motif chemokine receptor; DAP12, DNAX-activating protein of 12 kDa; Ig, immunoglobulin; ITAM, immunoreceptor tyrosine-based activation motif; ITIM, immunoreceptor tyrosine-based inhibitory motif; Siglec, sialic acid-binding immunoglobulin-like lectin. Others: see legend to Fig. 1