Table 3.

Performance of the PGS in predicting refractive error, myopia and hyperopia in independent samples of UK Biobank participants.

Ancestry	Incremental R2	AUROC
	Refractive error	Moderate hyperopia	Low myopia	Moderate myopia	High myopia (HM5)	High myopia (HM6)
European	0.190 (0.172–0.208)	0.742 (0.718–0.766)	0.728 (0.715–0.741)	0.754 (0.738–0.770)	0.774 (0.750–0.798)	0.783 (0.754–0.812)
African	0.020 (0.012–0.029)	0.610 (0.543–0.677)	0.582 (0.563–0.601)	0.596 (0.566–0.626)	0.586 (0.542–0.629)	0.584 (0.530–0.639)
South Asian	0.080 (0.066–0.096)	0.676 (0.631–0.721)	0.647 (0.631–0.664)	0.686 (0.664–0.708)	0.695 (0.664–0.726)	0.706 (0.668–0.743)
East Asian	0.060 (0.034–0.092)	0.610 (0.415–0.805)	0.653 (0.619–0.687)	0.660 (0.621–0.699)	0.648 (0.601–0.694)	0.672 (0.619–0.724)

Values in brackets are 95% confidence intervals. Samples sizes were: European (n = 6000); African (n = 4089); South Asian (n = 4641)’; East Asian (n = 978).

Abbreviations: Incremental R² = Variance in refractive error explained by PGS; AUROC = Area under the receiver operating characteristics curve; HM5 = High myopia (≤−5.00 D); HM6 = High myopia (≤−6.00 D).