Table 4.

Performance of the PGS in predicting refractive, myopia and hyperopia in young persons from the Generation R cohort.

Clinic visit	Incremental R2	AUROC
	Refractive error	Moderate hyperopia	Low myopia	Moderate myopia	High myopia (HM5)	High myopia (HM6)
9 years old	0.116 (0.079–0.153)	0.765 (0.695–0.825)	0.703 (0.654–0.751)	0.735 (0.600–0.854)	0.579 (0.567–0.592)	NA (only 1 case)
13 years old	0.141 (0.112–0.171)	0.774 (0.698–0.845)	0.691 (0.659–0.722)	0.691 (0.624–0.754)	0.739 (0.619–0.851)	0.783 (0.754–0.812)

Values in brackets are 95% confidence intervals. Samples sizes were: 9 year-olds visit (n = 1277); 13 year-olds visit (n = 1649).

Abbreviations: Incremental R² = Variance in refractive error explained by PGS; AUROC = Area under the receiver operating characteristics curve; HM5 = High myopia (≤−5.00 D); HM6 = High myopia (≤−6.00 D).