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. 2023 May 22;14:2937. doi: 10.1038/s41467-023-38539-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Left: Views of the XY-slice of the tomogram restored by REST; Right: Two XZ-slice views of conventionally denoised (Wiener filter) tomogram (top) and REST restored tomogram (bottom). The red arrows indicated the corresponding ribosomes (target signal). The red ellipse indicated the edge of the carbon film (non-target signal). B Left: A 3D rendering of the tomogram restored by REST. Right: The tomogram restored by REST (top) had a better restoration capability than that in the conventionally denoised tomogram (Wiener filtering) (bottom). Both the tomograms were rotated around the x-axis by 45° corresponding to left panel.