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. 2023 May 22;13:8218. doi: 10.1038/s41598-023-35502-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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FAS-AS1 promotes apoptosis through regulating mitochondria function and Fas splicing. (a) Representative picture of Mito-Tracker red labeled mitochondria in FAS-AS1 overexpressed cells or control cells. (b) Quantitative analysis of the representative picture’s fluorescence intensity. (c) Microstructure of mitochondria was observed by TEM in FAS-AS1 overexpressed cells or control cells. (d) Relative expression of sFas was determined by RT-qPCR 24 h after transfection with FAS-AS1 vector or control vector. (e) Relative expression of mFas was determined by RT-qPCR 24 h after transfection with FAS-AS1 vector or control vector. (f) The expression of several cell apoptosis signal regulators (cleaved-caspase 3, Bcl-2 and Bax) were examined by western blotting after transfection with FAS-AS1 vector or control vector. (g) The quantification of cleaved-caspase 3. (h) The quantification of Bax/Bcl-2. *P < 0.05, **P < 0.01.