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. 2023 May 22;14:2912. doi: 10.1038/s41467-023-38530-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, b Distribution of DEGs across the (left) broad cell types and (right) clusters after p-value combination meta-analysis. b Numbers of DEGs (y-axis) in each cluster for the male analysis, female analysis, and meta-analysis. c, d Overlap of meta-analysis DEGs with the individual analyses of the male and female datasets for (c) broad cell types and (d) clusters. The statistical test performed is Fisher combination of p-values as implemented in metaRNAseq, the test is one-sided, and the p-values were Benjamini Hochberg corrected. Source data are provided as a Source Data file.