Table 6.
Significant genes in mediation analysis in the Strong Heart Study that were differentially methylated in liver samples from the mouse model of in utero arsenic exposure compared to controls.
| Mouse gene | Outcome in mediation analysis in the Strong Heart Study | Number of DMRs (male / female) annotated to the gene in the mouse model | Number of DMPs (male / female) annotated to the gene in the mouse model | Genomic position of the DMPs |
|---|---|---|---|---|
| Tgfbr1 | CVD incidence | 5 / 4 | 1 / 0 | 47429393 |
| Arrdc2 | CVD incidence | 5 / 2 | 1 / 0 | 73359785 |
| Ago2 | CVD incidence | 8 / 2 | 2 / 0 | 72999018, 72977447 |
| Nisch | CVD incidence | 2 / 0 | 1 / 0 | 32008471 |
| Lmo7 | CVD incidence | 23 / 7 | 6 / 0 | 102168435, 102232355, 102232332, 102232208, 102296394, 102136457 |
| Adar | CVD mortality | 4 / 5 | 1 / 0 | 89534367 |
| Apbb2 | CVD mortality | 3 / 16 | 4 / 0 | 66999334, 66978308, 66724458, 66733745 |
| Nav2 | CVD mortality | 31 / 15 | 8 / 1 | 56849475, 56830246, 56621107, 56724015, 56583581, 56804011, 56665515, 56605002, 56747173 |
| Egr4 | CVD mortality | 2 / 2 | 1 / 0 | 85463274 |
| Lingo3 | CVD incidence and mortality | 0 / 1 | 2 / 0 | 80308751, 80306748 |
| Ubac1 | CVD incidence | 1 / 0 | 0 / 0 | - |
| Eppk1 | CVD incidence | 1 / 2 | 0 / 0 | - |
| Tecr | CVD incidence | 3 / 1 | 0 / 0 | - |
| Smoc2 | CVD incidence | 4 / 11 | 0 / 0 | - |
| Klf9 | CVD mortality | 4 / 4 | 0 / 0 | - |
| C1rl | CVD mortality | 4 / 0 | 0 / 0 | - |
| Emp2 | CVD mortality | 4 / 9 | 0 / 0 | - |
| Barhl2 | CVD mortality | 8 / 10 | 0 / 0 | - |
| Txnip | CVD incidence and mortality | 4 / 4 | 0 / 0 | - |
| Tymp | CVD incidence and mortality | 1 / 0 | 0 / 0 | - |
DMPs: Differentially Methylated Positions
DMRs: Differentially Methylated Regions