Table 1.
Baseline characteristics of COPD cases.
| All (N = 45) | Greater decliners‡ (N = 14) | Lesser decliners (N = 31) | P-Value† | ||
|---|---|---|---|---|---|
| Age* | 63.4 (± 7.75) | 64.2 (± 6.24) | 63.1 (± 8.41) | 0.65 | |
| Currently Smoking* | 15 (33.3%) | 5 (35.7%) | 10 (32.3%) | > 0.99 | |
| BMI* | 27.8 (± 4.91) | 27.9 (± 3.67) | 27.8 (± 5.43) | 0.93 | |
| Sex (Male) | 29 (64.4%) | 12 (85.7%) | 17 (54.8%) | 0.09 | |
| Race (White / Other) | 37/8 (82.2%) | 12/2 (85.7%) | 25/6 (80.6%) | > 0.99 | |
| ICS use* (yes) | 17 (37.8%) | 3 (21.4%) | 14 (45.2%) | 0.18 | |
| FEV1* (% predicted) | 75.6 (± 17.4) | 84.2 (± 13.1) | 71.1 (± 17.7) | 0.017 | |
| FEV1/FVC* | 0.58 (± 0.09) | 0.60 (± 0.08) | 0.57(± 0.10) | 0.27 | |
| FEV1* (L) | 2.27 (± 0.68) | 2.63 (± 0.60) | 2.11 (± 0.66) | 0.015 | |
| Visit 5 FEV1 (L) | 1.94 (± 0.67) | 1.97 (± 0.67) | 1.93 (± 0.68) | 0.85 | |
| Time from baseline to Visit 5 (yrs) | 6.31 (± 0.86) | 6.25 (± 0.76) | 6.33 (± 0.91) | 0.79 | |
| Time from baseline to bronchoscopy (months) | 20.3 (± 11.6) | 20.4 (± 10.0) | 20.3 (± 12.5) | 0.96 | |
| ∆FEV1 (mL/yr) | − 52.4 (± 43.3) | − 104.6 (± 32.0) | − 28.8 (± 21.5) | ||
Two-sample, two-tailed t-test or Fisher’s exact test were used to determine significant differences.
*Demographic information from baseline visit (Visit 1).
†P-values are associated with differences between greater decliner and lesser decliner groups.
‡Decline in FEV1 (mL/yr) ≥ 70 mL/year (see Methods).