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. 2023 Apr 21;39(5):btad280. doi: 10.1093/bioinformatics/btad280

Figure 2.

Figure 2.

Importance of features in AlphScore. Bar graph displaying permutation-based feature importance for the 25 most important features (total number of features = 218). The feature categories are color-coded. The delta sign represents the difference between the alternative amino acid and the reference amino acid for a given feature (see Section 2). Alt. AA, alternative amino acid; AA, amino acid; Solvent acc. s. area, solvent accessible surface area; VDW, Van der Waals; HSE-up, half-sphere exposure of the upper sphere; HSE-down, half-sphere exposure of the lower sphere; pLDDT, predicted Local Distance Difference Test, AlphaFold2 per-residue confidence score.