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. 2023 May 9;11:1196174. doi: 10.3389/fbioe.2023.1196174

FIGURE 4.

FIGURE 4

Application of bionic skin in burns/implants. (A) Microscope images of cell growth in the structure sustainable fabricated functional living skin (FLS) and analysis of cell migration and adhesion inside and outside of the bioprinting skin at day 1 and day 5. (B) Immunofluorescence staining showing the formation of hair follicles and blood vessels in FLS. Reproduced with permission from (Zhou et al., 2020). (C) Diagram of handheld instrument for controllable delivery of bionic. Reproduced with authorization from (Cheng et al., 2020). (D) 3D culture of MSC-fibrin-HA biomaterials at day 0 and day 7 after deposition showing the growth of MSC in biomaterial sheet. (E) In-situ deposition of MSC-containing fibrin-HA biomaterials into porcine full-thickness burn surface using the handheld device and recovery of the wound after 28 days. (F) Presentation of fabricated manual-cast 3D pigmented human skin constructs by bioprinting strategy. (G) H&E staining of pigmented human skin constructs obtained using the 3D bioprinting approach. Reproduced with permission from (Ng et al., 2018).