Table 1.

Institutions involved in the study.

Institution	City	Role and activity	Work package
Peking University Third Hospital	Beijing	Coordinating center	Convene expert committee, formulate the protocol and create the case report form (CRF) with statistics unit.
			Submit application to ethical committees.
			Train the protocol and outcomes measure.
			Present and disseminate the results with the permission of the sponsor.
			Enroll and follow-up the subjects.
The Second Hospital of Hebei Medical University	Shijiazhuang	Enrolling center	Participate in the seminar on protocol formulation and provide suggestions.
Henan Provinclal People’s Hosipital	Zhengzhou		Complete the training of the protocol and outcomes measure.
The First Affiliated Hosipital, Sun Yat-Sen University	Guangzhou
			Enroll and follow-up at least four subjects.
Guangdong Province Traditional Chinese Medical Hospital	Guangzhou
The Second Affiliated Hospital, Zhejiang University School of Medicine	Hangzhou
West China Hospital of Sichuan University	Chengdu
The First Affiliated Hospital of Xi’an Jiaotong University	Xi’an
Fujian Medical University Union Hospital	Fuzhou
The First Affiliated Hospital of Harbin Medical University	Harbin
Renmin Hospital of Wuhan University	Wuhan
/	/	Independent Data Monitoring Committee	Safety monitoring, efficacy monitoring, operational quality control, and suggestions for adjustment of trial design.
			Conduct an interim analysis and assess the risks and benefits for the subjects.
			Make a key recommendation whether the trial continues.
Wuhan Zhizhi Medical and Pharmaceutical Technology Co., Ltd.	Wuhan	Statistics unit	Participate in the design of the protocol and statistical plans.
			Establishment and management of Electronic Data Capture System and central randomization system.
			Blind codes.
			Statistical analysis.
Beijing Qi-Huang Technology Co., Ltd.	Beijing	Contract Research Organization	Monitor the trial.
Foshan Kaichuan Pharma Co., Ltd., Shanghai Pharma Rare Disease Medicine Co., Ltd	Foshan Shanghai	sponsor and funders	Provide funding.
			Provide HLSJ, riluzole tablets and simulants.
			Present and disseminate the results.
Medkey Med-Tech Development Co., Ltd.	Shanghai	Site Management Organization	Assist investigators in completing the screening, enrolling, and follow-up of the subjects.