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. 2023 May 9;13:1066427. doi: 10.3389/fonc.2023.1066427

Table 1.

Clinical characteristics of 67 patients with uterine serous carcinoma.

Characteristic Number
Age (mean, standard deviation, in years), range 65.8 +/- 8.3, 44-82
Race
Black
White
Asian
More than one
33 (49.2%)
32 (47.8%)
1 (1.5%)
1 (1.5%)
Ethnicity
Hispanic
Non-Hispanic
15 (22.4%)
52 (77.6%)
Treatment
Surgery 52 (78%)
TAH
“ + BSO
“ + BSO + PLND
“ + BSO + PLND + Omentectomy and debulking
2
2
10
38
Initial chemotherapy 65 (97%)
Carboplatin
“ + Paclitaxel
“ + Paclitaxel + Bevacizumab
“ + Paclitaxel + Herceptin
“ + Paclitaxel + Pembrolizumab
“ + Taxotere
“ + Taxotere + Bevacizumab
2
55
4
1
1
1
1
Radiation therapy 23 (34.3%)
FIGO Stage at diagnosis
I
II
III
IV
13 (19.4%)
3 (4.5%)
18 (26.9%)
33 (49.2%)
Metastatic disease 33 (49.2%)
Recurrent disease 27 (40.3%)
Mutational status
TP53
PIK3CA
FBXW7
ARID1A
PTEN
BRCA1
BRCA2
CTNNB1
ERBB2 alterations
AKT1,2,3
KRAS
55/58 (94.8%)
14/61 (22.9%)
10/60 (15%)
3/32 (9.4%)
5/57 (8.7%)
2/57 (3.5%)
2/57 (3.5%)
1/58 (1.7%)
12/37 (32.4%)
2/61 (3.3%)
1/61 (1.6%)
Immunohistochemistry
ER
PR
PTEN
TOP2A
TOP01
RRM1
MGMT
TS
TUBB3
43/65 (66.2%)
24/65 (36.9%)
51/56 (91.1%)
20/22 (90.9%)
14/22 (63.6%)
4/20 (20%)
3/5 (60%)
10/22 (45.5%)
11/22 (50%)

TAH, total hysterectomy; BSO, Bilateral salpingoophorectomy; PLND, pelvic lymph node dissection.