Table 4.
Glide scores (kcal/mole) for naringenin, phloretin, and ciprofloxacin in the proximal (chain C) and distal (chain A) binding sites of the AcrB model in the presence and absence of the EPI PAβN.
Compound | Proximal Site | Distal Site | ||
---|---|---|---|---|
- PAβN | + PAβN | - PAβN | + PAβN | |
Naringenin | -6.2 | -6.9 | -6.3 | -6.2 |
Phloretin | -6.7 | -6.8 | -5.3 | -4.7 |
Ciprofloxacin | -5.0 | -5.8 | -6.0 | -4.9 |