Table 2.

Modeling approaches and realistic clinical situations considered in order to test the possibility of clinical transfer of the models presented in the 21 selected articles.

First author	Year	Model typology and out-of-field dose components considered					Clinical examples reported
		Model compartmentalization	Patient scatter	Head scatter	Leakage	Neutrons	Cancer type or location of the treated tumor	RT techniques
Francois	1988	Single	✓	✓	✓		Pelvic - internal mammary fields	3DCRT
McParland	1992	Multi	✓	✓	✓		N/A	N/A
van der Giessen	1993	Multi	✓	✓	✓		Axilla - mantle field	3DCRT
van der Giessen	1994	Multi	✓	✓	✓		Mantle fields	3DCRT
Diallo	1996	Multi	✓	✓	✓		Breast - Head and Neck	3DCRT
van der Giessen	2001	Multi	✓	✓	✓		N/A	N/A
Benadjaoud	2012	Multi		✓	✓		N/A	N/A
Taddei	2013	Single	✓	✓	✓		Craniospinal irradiation	3DCRT
Veres	2014	Single	✓	✓	✓		CNS – STS - renal tumor – hepatoblastoma – lymphoma - nasopharynx - testis	3DCRT
Bezin	2015	Multi			✓		N/A	N/A
Jagetic	2015	Multi	✓	✓	✓		N/A	N/A
Sánchez-Nieto	2015	Multi	✓	✓	✓		Head and neck – prostate	IMRT-VMAT
Hauri	2016	Multi	✓	✓	✓		Prostate	3DCRT-IMRT-VMAT-FFF
De Saint-Hubert	2017	Single	✓	✓	✓		Craniospinal irradiations	3DCRT-IMRT-HT
Schneider	2017	Multi	✓	✓	✓		Prostate, see (58)	3DCRT-IMRT-HT-STEREO
Yoon	2017	Single	✓	✓	✓		Post-mastectomy radiotherapy	IMRT-VMAT-FFF
Gallagher	2018	Single	✓	✓	✓		Brain	3DCRT
Hauri	2019	Multi	✓	✓	✓	✓	Prostate.	3DCRT-IMRT-VMAT-FFF
Schneider	2019	Multi	✓	✓	✓		N/A	N/A
Wilson	2020	Multi	✓	✓	✓		Prostate	3DCRT
Sánchez-Nieto	2022	Single	✓	✓	✓		Prostate – lung	3DCRT - VMAT

CNS, central nervous system; STS, soft tissue sarcoma; FFF, flattening filter free; 3DCRT, three-dimensional conformal radiation therapy; IMRT, intensity-modulated radiotherapy; VMAT, volumetric modulated arc therapy; HT, helical tomotherapy; STEREO, stereotactic radiation therapy.