TABLE 2.

Morusin activity in different cancers.

Cancer	Targeted pathway	Impact of morusin	References
Hepatocellular carcinoma	STAT3 Pathway	G1 arrest	Cho et al. (2021)
Renal cell carcinoma	MAPK Pathway	Lowering ERK levels	Yang et al. (2020)
Colorectal cancer	PI3K/Akt Pathway	Inactivation of Akt	Zhou et al. (2021)
Nasopharyngeal carcinoma	ERK1/2 Pathway	Suppressing the expression of MMP-2	Huang et al. (2020)
Breast cancer	STAT3 Pathway	Suppressing Survivin and inducing Bax proteins	Kang et al. (2017)
Prostate cancer	STAT3 Pathway	Inhibition of phosphorylation of STAT3	Lim et al. (2015)
Gastric cancer	MAPK Pathway	Down-regulating c-Myc and CDKs	Wang et al. (2017)
Glioblastoma multiforme	STAT3 Pathway	Downregulation of Bcl-2 and upregulation of Bax	Guo et al. (2016)

Abbreviations: STAT3, Signal transducers and activators of transcription 3, MAPK, Mitogen-activated protein kinase, Bcl-2, B-cell lymphoma 2, CDK, Cyclin-dependent kinases, C-Myc, Cellular myelocytomatosis, BAX, Bcl-2-associated X protein, MMP, matrix metalloproteinase.