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Treatment algorithm for HFrEF. (A) Efficacy of foundational therapy in full spectrum of LVEF. The tapering of the horizontal blue bar suggests decreasing in efficacy in reducing heart failure endpoint. (B) Strategy for in-hospital initiation of foundational therapies for HFsrEF. (C) Role of additional therapy for HFsrEF. Abbreviations as in Figure 2 and 3.
