Supplemental Table 1. Timing of in-hospital initiation and definitions of hemodynamically stable conditions.

	Timing	Hemodynamic stability
		SBP	O2 supply	IV diuretic	IV vasodilator	IV inotrope
PIONEERS1	≥ 24 hours to 10 days after hospitalization	≥ 100 mmHg	No mention	No increase in dose ≥ 6 hours	No use ≥ 6 hours	No use ≥ 24 hours
SOLOIST-WHFS2	Before discharge to ≤ 3 days after discharge	≥ 100 mmHg	No O2 supply or mechanical ventilation ≥ 24 hours	No iv diuretic	No iv vasodilator (except nitrates) ≥ 24 hours	No use ≥ 24 hours
EMPULSES3	≥ 24 hours to < 5 days after hospitalization	≥ 100 mmHg	No mention	No increase in dose ≥ 6 hours	No use ≥ 6 hours	No use ≥ 24 hours
STRONG-HFS4	Hospital admission within the 72 hours prior to screening	≥ 100 mmHg	No mention	No mention	No mention	No mention

IV, intravenous; SBP, systolic blood pressure.