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Supplemental Table 2. Primary endpoint in recent heart failure trials.

Trials Primary endpoint
PARADIGM-HFS5 Cardiovascular death + hospitalization for heart failure
PARAGON-HFS6 Cardiovascular death + total hospitalizations for heart failure
DAPA-HFS7 Cardiovascular death + worsening heart failure
DELIVERS8 Cardiovascular death + worsening heart failure
EMPEROR-ReducedS9 Cardiovascular death + hospitalization for heart failure
EMPEROR-PreservedS10 Cardiovascular death + hospitalization for heart failure
SOLOIST-WHFS2 Cardiovascular death + total hospitalizations for heart failure + worsening heart failure
VICTORIAS11 Cardiovascular death + hospitalization for heart failure
GALACTIC-HFS12 Cardiovascular death + worsening heart failure