Fig. 1.

Mice on Mg2800 diet had reduced arthritis severity in KSIA. A) Timeline of the experiment: relative to the induction of KSIA: day-14 diet starts; day 0 and day 2 KRN serum injection, and day 15 end of the diet and KSIA scoring period; B) Arthritis severity scores were significantly decreased in mice receiving the Mg2800 diet compared with Mg500 (n = 25 per treatment group; ∗p = 0.0005 and ∗∗p < 0.0001). C) Representative images of joints from both Mg diet groups at day 15 (hematoxylin/eosin, H&E, staining; left panels are lower magnification, and box area are magnified on the right panels; day 12, H&E, size bars = 500 μM and 250 μM); D) Articular histology scoring for synovial inflammation, hyperplasia, and erosions of cartilage (∗p ≤ 0.03; n = 9–10 per group) and bone (∗∗p < 0.002; n = 9–10 per group).