Table 1.
Selected list of abundant metagenomic pathways identified in the FMT recipients (from a list of 313).a
| Pathway description | ID number | p-value | Mg2800 abundance | Mg500 abundance | fold difference |
|---|---|---|---|---|---|
| Increased abundance in recipients from Mg2800 FMT | |||||
| coxM, cutM; aerobic carbon-monoxide dehydrogenase medium subunit [EC:1.2.5.3] | K03519 | 0.0021 | 1140.86 | 16.89 | 67.6 |
| rspA, manD; mannonate dehydratase [EC:4.2.1.8] | K08323 | 0.0022 | 2196.71 | 43.33 | 50.7 |
| rspB; L-gulonate 5-dehydrogenase [EC:1.1.1.380] | K08322 | 0.0010 | 1663.00 | 42.33 | 39.3 |
| phnK; putative phosphonate transport system ATP-binding protein | K05781 | 0.0010 | 21.50 | 0.61 | 35.2 |
| phnM; alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase [EC:3.6.1.63] | K06162 | 0.0010 | 21.50 | 0.61 | 35.2 |
| D-arabinitol dehydrogenase (NADP (+)) | EC:1.1.1.287 | 0.0010 | 41.86 | 1.22 | 34.2 |
| 4-hydroxyphenylacetate decarboxylase | EC:4.1.1.83 | 0.0010 | 125.57 | 3.67 | 34.2 |
| asrB; anaerobic sulfite reductase subunit B | K16951 | 0.0013 | 1273.07 | 39.03 | 32.6 |
| Methylmalonate-semialdehyde dehydrogenase (CoA acylating) | EC:1.2.1.27 | 0.0008 | 588.57 | 24.33 | 24.2 |
| mmsA, iolA, ALDH6A1; malonate-semialdehyde dehydrogenase (acetylating)/methylmalonate-semialdehyde dehydrogenase [EC:1.2.1.18 1.2.1.27] | K00140 | 0.0008 | 588.57 | 24.33 | 24.2 |
| asrC; anaerobic sulfite reductase subunit C | K00385 | 0.0011 | 744.50 | 32.69 | 22.8 |
| ulaG; L-ascorbate 6-phosphate lactonase [EC:3.1.1.-] | K03476 | 0.0008 | 1771.64 | 81.10 | 21.8 |
| dcyD; D-cysteine desulfhydrase [EC:4.4.1.15] | K05396 | 0.0007 | 710.57 | 38.11 | 18.6 |
| 2-deoxy-D-gluconate 3-dehydrogenase | EC:1.1.1.125 | 0.0008 | 1464.79 | 133.94 | 10.9 |
| kduD; 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase [EC:1.1.1.127] | K00065 | 0.0008 | 1464.79 | 133.94 | 10.9 |
| TC.CITMHS; citrate-Mg2+:H+ or citrate-Ca2+:H+ symporter, CitMHS family | K03300 | 0.0007 | 143.00 | 14.22 | 10.1 |
| prpR; transcriptional regulator, propionate catabolism operon regulatory protein | K02688 | 0.0010 | 85.14 | 23.33 | 3.6 |
| Superpathway of L-tryptophan biosynthesis | PWY-6629 | 0.0023 | 588.03 | 181.67 | 3.2 |
| UDP-2,3-diacetamido-2,3-dideoxy-α-D-mannuronate biosynthesis | PWY-7090 | 0.0004 | 184.03 | 67.61 | 2.7 |
| mannan degradation | PWY-7456 | 0.0001 | 13612.67 | 5866.52 | 2.3 |
| tnaA; tryptophanase [EC:4.1.99.1] | K01667 | 0.0004 | 2503.02 | 1191.11 | 2.1 |
| Acetaldehyde dehydrogenase (acetylating) | EC:1.2.1.10 | 0.0013 | 7466.29 | 7069.63 | 1.1 |
| L-methionine biosynthesis I | HOMOSER-METSYN-PWY | 0.0018 | 1377.44 | 1304.59 | 1.1 |
| superpathway of S-adenosyl-L-methionine biosynthesis | MET-SAM-PWY | 0.0016 | 2072.66 | 1985.72 | 1.0 |
| arcA; arginine deiminase [EC:3.5.3.6] | K01478 | 0.0025 | 1221.59 | 1182.67 | 1.0 |
| superpathway of L-methionine biosynthesis (transsulfuration) | PWY-5347 | 0.0015 | 2973.71 | 2886.48 | 1.0 |
| Decreased abundance in recipients from Mg2800 FMT | |||||
| SCD, desC; stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1] | K00507 | 0.0011 | 13.71 | 81.67 | −6.0 |
| FAH, fahA; fumarylacetoacetase [EC:3.7.1.2] | K01555 | 0.0010 | 13.71 | 81.11 | −5.9 |
| FAB2, SSI2, desA1; acyl-[acyl-carrier-protein] desaturase [EC:1.14.19.2 1.14.19.11 1.14.19.26] | K03921 | 0.0010 | 13.71 | 81.11 | −5.9 |
| K09992; uncharacterized protein | K09992 | 0.0010 | 13.71 | 81.11 | −5.9 |
| lcyB, crtL1, crtY; lycopene beta-cyclase [EC:5.5.1.19] | K06443 | 0.0010 | 13.71 | 81.11 | −5.9 |
| Aldehyde dehydrogenase (NADP (+)) | EC:1.2.1.4 | 0.0011 | 14.29 | 81.11 | −5.7 |
| chlI, bchI; magnesium chelatase subunit I [EC:6.6.1.1] | K03405 | 0.0011 | 14.29 | 81.11 | −5.7 |
| aldH; NADP-dependent aldehyde dehydrogenase [EC:1.2.1.4] | K14519 | 0.0011 | 14.29 | 81.11 | −5.7 |
| Magnesium chelatase | EC:6.6.1.1 | 0.0011 | 14.29 | 81.11 | −5.7 |
| L-tyrosine degradation I | TYRFUMCAT-PWY | 0.0008 | 205.67 | 334.25 | −1.6 |
| coaW; type II pantothenate kinase [EC:2.7.1.33] | K09680 | 0.0009 | 7363.63 | 9041.14 | −1.2 |
| 4-hydroxy-2-oxoheptanedioate aldolase | EC:4.1.2.52 | 0.0021 | 841.86 | 1023.44 | −1.2 |
| Superpathway of heme biosynthesis from glycine | PWY-5920 | 0.0002 | 2303.94 | 2707.64 | −1.2 |
| coxC, ctaE; cytochrome c oxidase subunit III [EC:1.9.3.1] | K02276 | 0.0002 | 1290.71 | 1508.11 | −1.2 |
| Superpathway of L-lysine, L-threonine and L-methionine biosynthesis I | P4-PWY | 0.0018 | 4131.51 | 4676.90 | −1.1 |
| Superpathway of arginine and polyamine biosynthesis | ARG + POLYAMINE-SYN | 0.0021 | 2165.21 | 2257.81 | −1.0 |
a
Day 12 post FMT; ordered according to fold-difference; p-values based on ANOVA; Bold entries represent pathways and processes mentioned in the manuscript.