TABLE 3.

Associations of Exam 1 hiatus hernia (HH) with death by MUC5B (rs35705950) risk allele (T) carrier status

Carrier  status	Participants (n)	Total person-years	Events (n)	Event rate per 1000 person-years	Hazard ratio (95% CI)	p-value
GG
No HH	2421	36 999	674	18.2 (16.7–19.6)	1.00 (reference)
HH	169	2474	52	21.0 (15.9–27.4)	1.06 (0.79–1.41)	0.70
GT/TT
No HH	310	4830	71	14.7 (11.6–18.4)	1.00 (reference)
HH	33	472	13	27.5 (15.3–45.9)	2.05 (1.12–3.74)	0.02

Hazard ratios are reported among those with HH compared with those without HH (reference group). Cox regression model in which the primary exposure variable is HH. Adjusted for baseline sex, race/ethnicity, smoking status, cigarette pack-years, percent emphysema, education attainment, height, weight, statin use, blood pressure medication use, systolic and diastolic blood pressure, Agatston coronary artery calcium score, diabetes, total intentional exercise, history of cancer, study site, principal components of genetic ancestry, MUC5B (rs35705950) carrier status (GG versus GT/TT), and interaction term “HH×MUC5B carrier status”. p-value for MUC5B (rs35705950) interaction=0.05. Analysis restricted to participants <80 years old at baseline.