Table. Clinical Characteristics of the Atherosclerosis Risk in Communities Study Sample by pV142I Carrier Status at Visit 1 (1996-1998) and Visit 6 (2016-2017).
| Clinical characteristic | Visit 1 | Visit 6 | ||||
|---|---|---|---|---|---|---|
| pV142I noncarrier (n = 3732) | pV142I carrier (n = 124) | P value | pV142I noncarrier (n = 885) | pV142I carrier (n = 38) | P value | |
| Age, y, mean (SD) | 54.0 (5.8) | 53.5 (5.5) | .37 | 79.1 (4.8) | 78.1 (4.3) | .20 |
| Male, No. (%) | 1408 (37.7) | 45 (36.3) | .75 | 271 (30.6) | 9 (23.7) | .36 |
| Female, No. (%) | 2324 (62.3) | 79 (63.7) | 614 (69.4) | 29 (76.3) | ||
| Physical examination, mean (SD) | ||||||
| Systolic blood pressure, mm Hg | 129 (21) | 131 (20) | .14 | 137 (20) | 136 (22) | .63 |
| Diastolic blood pressure, mm Hg | 80 (12) | 82 (13) | .09 | 67 (10) | 64 (9) | .09 |
| Heart rate, beats/min | 67 (11) | 68 (11) | .24 | 64 (11) | 65 (11) | .60 |
| Body mass indexa | 29.7 (6.2) | 29.1 (6.0) | .35 | 30.1 (6.1) | 27.9 (6.4) | .04 |
| Comorbidities, No. (%) | ||||||
| Hypertension | 2068 (55.7) | 72 (58.5) | .53 | 792 (91.1) | 34 (89.5) | .72 |
| Diabetes | 715 (19.7) | 25 (20.7) | .79 | 395 (49.1) | 16 (43.2) | .49 |
| Coronary heart disease | 143 (3.9) | 5 (4.1) | .92 | 92 (10.5) | 5 (13.2) | .61 |
| Heart failure | 245 (6.7) | 10 (8.2) | .51 | 83 (9.4) | 9 (23.7) | .004 |
| Stroke | 107 (2.9) | 5 (4.1) | .44 | 67 (7.6) | 3 (7.9) | .95 |
| Laboratory testing, mean (SD) | ||||||
| Estimated glomerular filtration rate, mL/min/1.78 m2 | 103 (27) | 103 (24) | .85 | 62 (21) | 64 (18) | .72 |
| Low-density lipoprotein, mg/dL | 138 (43) | 131 (43) | .11 | 108 (33) | 101 (28) | .30 |
a
Body mass index was calculated as weight in kilograms divided by height in meters squared.