Table 2.
Association of MetS (2020 Edition) and metabolic scores with MMSE score, and specific cognitive domains using linear regression analysis among hemodialysis patients
| Characteristics | Model 1 | Model 2 | Model 3 | |||
|---|---|---|---|---|---|---|
| β (95%CI) | P | β (95%CI) | P | β (95%CI) | P | |
| MetS (2020 Edition) | ||||||
| MMSE score | − 0.496 (− 0.700, − 0.292) | < 0.001 | − 0.317 (− 0.517, − 0.117) | 0.002 | − 0.324 (− 0.523, − 0.125) | < 0.001 |
| Orientation | − 0.108 (− 0.172, − 0.044) | 0.001 | − 0.074 (− 0.138, − 0.011) | 0.022 | − 0.075 (− 0.139, − 0.012) | 0.020 |
| Registration | − 0.039 (− 0.063, − 0.014) | 0.002 | − 0.026 (− 0.051, − 0.001) | 0.040 | − 0.026 (− 0.051, − 0.002) | 0.036 |
| Attention and calculation | − 0.068 (− 0.150,0.014) | 0.102 | − 0.015 (− 0.096, 0.066) | 0.712 | − 0.025 (− 0.105, 0.056) | 0.550 |
| Recall | 0.091 (− 0.139, − 0.042) | < 0.001 | − 0.056 (− 0.104, − 0.007) | 0.024 | − 0.056 (− 0.104, − 0.008) | 0.021 |
| Language | − 0.188 (− 0.257, − 0.119) | < 0.001 | − 0.143 (− 0.211, − 0.074) | < 0.001 | − 0.141 (− 0.209, − 0.072) | < 0.001 |
| siMS score | ||||||
| MMSE score | − 0.192 (− 0.270, − 0.113) | < 0.001 | − 0.126 (− 0.203, − 0.049) | 0.001 | − 0.123 (− 0.199,− 0.046) | 0.002 |
| Orientation | − 0.055 (− 0.080, − 0.030) | < 0.001 | − 0.042 (− 0.066, − 0.017) | 0.001 | − 0.041 (− 0.065,− 0.016) | 0.001 |
| Registration | − 0.013 (− 0.023, − 0.004) | 0.007 | − 0.009 (− 0.018, 0.001) | 0.073 | − 0.009 (− 0.018, 0.001) | 0.078 |
| Attention and calculation | − 0.036 (− 0.068, − 0.005) | 0.025 | − 0.011 (− 0.042, 0.020) | 0.476 | − 0.012 (− 0.043, 0.019) | 0.434 |
| Recall | − 0.021 (− 0.040, − 0.003) | 0.025 | − 0.012 (− 0.031, 0.006) | 0.194 | − 0.011 (− 0.030, 0.007) | 0.227 |
| Language | − 0.059 (− 0.086, − 0.033) | < 0.001 | − 0.046 (− 0.072, − 0.019) | 0.001 | − 0.044 (− 0.071, − 0.018) | 0.001 |
| CMI | ||||||
| MMSE score | − 0.213 (− 0.312, − 0.114) | < 0.001 | − 0.166 (− 0.263, − 0.070) | 0.001 | − 0.160 (− 0.256, − 0.065) | 0.001 |
| Orientation | − 0.076 (− 0.107, − 0.045) | < 0.001 | − 0.066 (− 0.097, − 0.036) | < 0.001 | − 0.066 (− 0.096, − 0.036) | < 0.001 |
| Registration | − 0.012 (− 0.024, 0.000) | 0.050 | − 0.009 (− 0.073, − 0.023) | < 0.001 | − 0.008 (− 0.020, 0.004) | 0.168 |
| Attention and calculation | − 0.024 (− 0.064, 0.015) | 0.229 | − 0.008 (− 0.047, 0.031) | 0.685 | − 0.006 (− 0.045, 0.032) | 0.750 |
| Recall | − 0.016 (− 0.039, 0.008) | 0.184 | − 0.009 (− 0.032, 0.015) | 0.469 | − 0.007 (− 0.030, 0.017) | 0.579 |
| Language | − 0.080 (− 0.114, − 0.047) | < 0.001 | − 0.070 (− 0.103, − 0.037) | < 0.001 | − 0.069 (− 0.102, − 0.036) | < 0.001 |
| MetSSS | ||||||
| MMSE score | − 0.231 (− 0.303, − 0.159) | < 0.001 | − 0.106 (− 0.180,-0.033) | 0.005 | − 0.107 (− 0.180, − 0.034) | 0.004 |
| Orientation | − 0.054 (− 0.076, − 0.031) | < 0.001 | − 0.027 (− 0.050, − 0.004) | 0.022 | − 0.027 (− 0.050, − 0.004) | 0.023 |
| Registration | − 0.018 (− 0.026, − 0.009) | < 0.001 | − 0.009 (− 0.018, 0.000) | 0.043 | − 0.009 (− 0.019, − 0.000) | 0.042 |
| Attention and calculation | − 0.064 (− 0.093, − 0.035) | < 0.001 | − 0.011 (− 0.040, 0.019) | 0.474 | − 0.014 (− 0.043, 0.016) | 0.355 |
| Recall | − 0.028 (− 0.045, − 0.011) | 0.001 | − 0.016 (− 0.033, 0.001) | 0.067 | − 0.013 (− 0.031, 0.004) | 0.132 |
| Language | − 0.064 (− 0.087, − 0.039) | < 0.001 | − 0.040 (− 0.065, − 0.015) | 0.002 | − 0.039 (− 0.064, − 0.014) | 0.002 |
Model 1, crude model; Model 2, adjusted for age, sex; Model 3, adjusted for age, sex, educational level, smoking history, alcohol history, living alone, dialysis vintage, dialysis modality, dialysis access, and hemoglobin levels. MetS Metabolic syndrome, MMSE Mini-mental state examination, β Unstandardized coefficient, CI Confidence interval, siMS Metabolic syndrome score, CMI Cardiometabolic index, MetSSS Metabolic syndrome severity score