Table 3.
Association of MetS (2020 Edition), its components, number and metabolic scores with incident MCI using logistic regression analysis among hemodialysis patients
| Characteristics | Model 1 | Model 2 | Model 3 | Mutual model | ||||
|---|---|---|---|---|---|---|---|---|
| OR(95%CI) | P | OR(95%CI) | P | OR(95%CI) | P | OR(95%CI) | P | |
| MetS (2020 Edition) | 1.31 (1.17, 1.47) | < 0.001 | 1.21 (1.08, 1.36) | 0.001 | 1.22 (1.08, 1.37) | 0.001 | – | |
| MetS component | ||||||||
| Abdominal obesity (%) | 1.35 (1.20, 1.51) | < 0.001 | 1.14 (1.01, 1.29) | 0.032 | 1.14 (1.01, 1.28) | 0.039 | 1.15 (1.01, 1.30) | 0.031 |
| Hypertriglyceridemia (%) | 1.12 (0.99, 1.25) | 0.054 | 1.10 (0.98, 1.23) | 0.105 | 1.11 (0.99, 1.24) | 0.089 | 1.09 (0.97, 1.23) | 0.145 |
| Low HDL-c (%) | 1.06 (0.95, 1.19) | 0.311 | 1.11 (0.99, 1.24) | 0.088 | 1.11 (0.99, 1.25) | 0.079 | 1.04 (0.85, 1.27) | 0.695 |
| Hyperglycemia (%) | 1.30 (1.16, 1.47) | < 0.001 | 1.18 (1.04, 1.33) | 0.010 | 1.17 (1.04, 1.33) | 0.011 | 1.28 (0.98, 1.68) | 0.070 |
| High blood pressure (%) | 1.24 (0.97, 1.59) | 0.087 | 1.24 (0.96, 1.59) | 0.099 | 1.24 (0.96, 1.60) | 0.093 | 1.09 (0.97, 1.22) | 0.168 |
| Number of MetS components | – | |||||||
| 0 | References | References | References | |||||
| 1 | 1.73 (0.88, 3.40) | 0.115 | 1.79 (0.90, 3.55) | 0.098 | 1.86 (0.93, 3.71) | 0.078 | ||
| 2 | 1.99 (1.03, 3.87) | 0.041 | 1.93 (0.99, 3.76) | 0.055 | 2.03 (1.04, 3.98) | 0.039 | ||
| 3 | 2.56 (1.32, 4.95) | 0.005 | 2.36 (1.21, 4.60) | 0.012 | 2.51 (1.28, 4.90) | 0.007 | ||
| 4 | 2.60 (1.34, 5.05) | 0.005 | 2.24 (1.15, 4.38) | 0.018 | 2.35 (1.20, 4.62) | 0.013 | ||
| 5 | 3.52 (1.79, 6.91) | < 0.001 | 2.78 (1.40, 5.51) | 0.003 | 2.94 (1.48, 5.84) | 0.002 | ||
| siMS score | 1.09 (1.05, 1.14) | < 0.001 | 1.06 (1.02, 1.11) | 0.007 | 1.06 (1.02, 1.11) | 0.008 | ||
| CMI | 1.10 (1.04, 1.16) | 0.001 | 1.08 (1.02, 1.14) | 0.006 | 1.08 (1.02, 1.14) | 0.009 | ||
| MetSSS | 1.12 (1.08, 1.16) | < 0.001 | 1.06 (1.02, 1.11) | 0.007 | 1.06 (1.02, 1.11) | 0.006 | ||
Model 1, crude model; Model 2, adjusted for age, gender; Model 3, adjusted for age, gender, educational level, smoking history, alcohol history, living alone, dialysis vintage, dialysis modality, dialysis access, and hemoglobin levels. Mutual Model, adjusted for other MetS components as continuous variables based on Model 3, respectively. MetS Metabolic syndrome, MCI Mild cognitive impairment, OR Odds ratio, CI Confidence interval, HDL High density lipoprotein, siMS Metabolic syndrome score, CMI Cardiometabolic index, MetSSS Metabolic syndrome severity score