Table 2.
MIC of antibiotics against Shigella
| Antibiotic | Type | Action site | MICa (µg/mL) | ||
|---|---|---|---|---|---|
| S. dysenteriae CGMCC 1.1869 | S. flexneri CGMCC 1.1868 | S. flexneri CGMCC 1.10599 | |||
| Erythromycin | macrolides | tRNA | 0.125 (S) | 4 (I) | 0.06 (S) |
| Gentamicin Sulphate | aminoglycoside | ribosomal 30S subunits | 0.25 (S) | 8 (R) | 0.125 (S) |
| Chloramphenicol | amyl alcohol | peptide linkage | 0.06 (S) | 0.06 (S) | 0.06 (S) |
| Cefotaxime | β- lactam | cell wall | 0.06 (S) | 0.06 (S) | 0.06 (S) |
| Cefoxitin | β- lactam | cell wall | 0.06 (S) | 2 (S) | 0.06 (S) |
| Cephalothin | β- lactam | cell wall | 0.06 (S) | 0.125 (S) | 0.06 (S) |
| Cardelmycin | aminocoumarin | DNA gyrase | 0.125 (S) | 8 (R) | 0.125 (S) |
| Tetracycline hydrochloride | tetracyclines | rRNA | 0.06 (S) | 0.06 (S) | 0.06 (S) |
| Polymyxin B sulfate | polypeptides | LPS | 0.125 (S) | 2 (S) | 0.06 (S) |
aS, I, and R represented the degree of strain response to each antibiotic, with sensitivity, intermediary and resistance, respectively