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. 1981 Jul;36(7):517–522. doi: 10.1136/thx.36.7.517

Exercise-induced bronchoconstriction as an expression of bronchial hyperreactivity: a study of its mechanisms in children.

H J Neijens, T Wesselius, K F Kerrebijn
PMCID: PMC1020434  PMID: 6797085

Abstract

The mechanism of exercise-induced bronchoconstriction (EIB) was studied by observing the protective effects of several aerosol agents in a double-blind, randomised trial. Exercise-induced bronchoconstriction was not affected by placebo, but was reduced by each agent used (p less than 0.001). Blocking the parasympathetic system had the weakest effect, while beta 2 adrenergic stimulation produced the strongest effect which was significantly different from the parasympatholytic (p less than 0.02). The effect of the mast cell stabilizer, sodium cromoglycate (SCG) was found to be intermediate. However in some patients SCG had a stronger effect than the beta 2 adrenergic agonist. A relationship was found between EIB and bronchial hyperreactivity induced by histamine (p less than 0.05).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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