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. 2023 May 23;257:115512. doi: 10.1016/j.ejmech.2023.115512

Table 2.

Microsomal stability of compounds 11b-11f on species of human and mouse.

Entry no. t1/2 (minute)b
human mouse
11b 11.60 7.74
11c 18.03 4.82
11d 42.20 33.75
11e >120 >120
11f 3.25 0.85
nirmatrelvira 35.5 17.7
a

Used as a positive control.

b

The tested concentration of compounds was 1 μM.