Table 3.

Single dose PK of compounds 11b and 11e.

Entry no.	Administrationa	T1/2 (h)	Cmax (ng/mL)	AUC(0-t) (h*ng/mL)	AUC(0-∞) (h*ng/mL)	F (%)
11b	IV	0.47 ± 0.09	-b	2281 ± 325	2284 ± 324	–
	PO	0.91 ± 0.09	1597 ± 135	2155 ± 168	2161 ± 171	47.25 ± 3.69
11e	IV	0.74 ± 0.04	–	3783 ± 389	3857 ± 388	–
	PO	0.76 ± 0.03	3342 ± 1243	5143 ± 303	5153 ± 306	67.98 ± 4.01
nirmatrelvirc	IV	0.42 ± 0.10	–	2240 ± 101	2241 ± 101	–
	PO	0.51 ± 0.10	1819 ± 695	1023 ± 195	1029 ± 202	22.85 ± 4.35

^aSingle IV dose was 10 mg/kg and PO dose was 20 mg/kg.

^bNot tested.

^cUsed as a positive control.