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. 2023 May 23;257:115512. doi: 10.1016/j.ejmech.2023.115512

Table 5.

Single dose PK of compound 11j.

Administrationa T1/2 (h) Cmax (ng/mL) AUC(0-t)
(h*ng/mL)
AUC(0-∞)
(h*ng/mL)
F (%)
IV 1.38 ± 0.2 -b 33780 ± 4258.5 34308 ± 4670
PO 2.1 ± 0.8 9327 ± 3316 32473 ± 16572.8 33207 ± 16862 48.1
a

Single IV dose was 10 mg/kg and PO dose was 20 mg/kg.

b

Not tested.