Table 5.

Cox proportional-hazard regression analysis of ICU admission and oxygen weaning risks.

	ICU Admission						Oxygen Weaning
	Unadjusted			Adjusted †			Unadjusted			Adjusted ‡
	HR	CI 95%	p	HR	CI 95%	p	HR	CI 95%	p	HR	CI 95%	p
S20	1.24	1.09–1.42	<0.01	1.17	0.99–1.37	0.06	0.86	0.78–0.95	0.04	0.97	0.86–1.09	0.63
S24	1.21	1.08–1.35	<0.01	1.16	1.01–1.33	0.04	0.88	0.82–0.96	<0.01	0.97	0.88–1.07	0.52
S60	1.09	1.02–1.18	0.02	1.06	0.97–1.16	0.21	0.94	0.89–0.98	<0.01	1.00	0.95–1.05	0.99
S72	1.08	1.02–1.15	0.01	1.06	0.99–1.14	0.12	0.95	0.91–0.99	<0.01	0.99	0.95–1.04	0.77
Age	0.98	0.93–1.02	0.28				0.98	0.96–1.01	0.18
Male	2.59	0.33–20.25	0.36				0.90	0.43–1.88	0.77
Disease duration	0.85	0.51–1.42	0.53				1.07	0.86–1.33	0.56
CRP	1.00	1.00–1.01	0.23				1.00	0.99–1.00	0.09
pO2/FiO2	0.99	0.98–1.00	0.20				1.01	1.00–1.01	<0.01
Cytokine storm	1.89	0.41–8.78	0.42				0.17	0.04–0.72	0.16
IL-6 *	2.13	1.12–4.07	0.02				0.69	0.54–0.88	<0.02
IL-8 *	2.10	1.14–3.88	0.02				0.60	0.39–0.94	0.03
IL-1 *	2.71	0.78–9.43	0.12				0.93	0.49–1.76	0.82
TNF-α	0.999	0.92–1.09	0.98				0.94	0.90–0.99	0.02
TCZ/SAR	0.851	0.26–2.79	0.79				1.12	0.613–2.03	0.72

† Adjusted for Log IL-6 and Log IL-8; ‡ Adjusted for presence of Cytokine storm, pO₂/FiO₂, Log IL-6, Log IL-8 and TNF-α; * Log-transformed. Abbreviations: ICU intensive care unit, HR Hazard Ratio, CI confidence interval, LDH lactate dehydrogenases, IL interleukin, TNF tumor necrosis factor, TCZ tocilizumab, SAR sarilumab. Statistically significant associations are highlighted in grey.