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. 2023 May 10;13(2):218–236. doi: 10.3390/jox13020017

Table 1.

Summary of case reports.

Study Year Age
(Years)
SARM Dose (mg) Duration (Weeks) Time from Stopping to Symptoms (days) Presenting Symptoms Imaging Biopsy R Factor Treatment and Outcome
Baliss et al. [24] 2020 31 RAD-140 12 3 days of epigastric pain, jaundice and pruritis, scleral icterus MRI abdomen normal Labs down-trended after 1 month
Barbara et al. [11] 2020
32 LGD-4033 10 2 1–7 diffuse itching, jaundice, acholic stool, intermittent
abdominal pain, nausea, 40 lbs. weight loss, scleral icterus
US and CT-hepatomegaly
MRCP, small hepatic cyst and splenomegaly, otherwise normal
Cholestatic
hepatitis with mild portal, periportal, perisinusoidal fibrosis
Barbara et al. [18] 2020 52 RAD-140, LGD-4033 17.86, 10 7 1–7 Right upper quadrant pain, pruritus, and greasy diarrhea, scleral icterus, jaundice MRI abdomen normal Diffuse centrilobular
canalicular cholestasis, mild portal and periportal fibrosis
0.2 Stop alcohol consumption, improvement in labs at 3 months
Bittner et al. [25] 2020 34 LGD-4033 7.5 4 7 Decreased appetite, worsening pruritus,
dark amber urine, and cognitive ‘clouding’, jaundice, scleral icterus
US normal. CT abdomen–mild splenomegaly Inflammation and diffuse cholestasis
Flores et al. [26] 2020 24 LGD-4033 9 7 jaundice, anorexia, nausea,
lethargy, 5 kg weight loss
US normal 8.22 Labs normalized after 4 months
Flores et al. [26] 2020 49 RAD-140 4 20–30 Jaundice and
itching
Moderate
cholestasis with ductopenia and minimal fibrosis
and inflammation,
5 Ursodiol and cholestyramine, labs normalized after 12 months
Bedi et al. [12] 2021
40 Enobosarm 8 Jaundice, anorexia, weight loss, lethargy, and diarrhea, scleral icterus US, CT abdomen, and MRCP normal centrilobular cholestasis with
yellow-green bile in hepatocytes and canaliculi
0.8 Improvement in labs over several months of follow up
Gould et al. [14] 2021 36 Ostarine and Carderine 8 35 Asynchronous bilateral Achilles tendon rupture after two 4-week cycles of SARM compounds
Kintz et al. [9] 2021 43 MK-2866, Carderine 20, 20 0.7 10 Patient presented with severe rhabdomyolysis after cycling 74.6 miles with extreme elevations of ALT, AST, and CK
Koller et al. [16] 2021 19 LGD-4033 7 0 Patient cycled 4 weeks on, 4 weeks off. Restarted the cycle for 3 weeks and stopped after noticing dark urine, yellow
sclera, and thinner light-colored stools
US abdomen-normal Mild septal fibrosis, canalicular cholestasis in the
hepatocytes with numerous biliary plugs
3.9 1000 mg ursodeoxycholic acid (UDCA) daily for 2 mo. Labs normalized after 3 months
Koller et al. [16] 2021 28 LGD-4033, Ostarine 0 For 3 months took unknown amount of SARM. After 3-week break, a formulation of SARM bought on internet was taken for 4 doses, reasons for seeking medical care unclear MRI abdomen hepatomegaly without biliary pathology Mild bridging fibrosis, destruction of bile ducts, centrilobular canalicular
cholestasis with numerous bile plugs
3.3 300 mg intravenous N-acetyl cysteine 4 times daily, 1000
mg oral UDCA daily, and 450 mg silymarin daily. Labs significantly improved at 3 months
Cardaci et al. [27] 2022 25 LGD-4033, MK-677 10, 15 5 This was an efficacy case report, no SAE’s reported, however, ALT increased from 20 IU/L to 61 IU/L after 5 weeks. The ALT returned to baseline after 4 weeks off SARM
Khan et al. [28] 2022 29 4 Jaundice, pruritus, fatigue, scleral icterus, light-colored stools, dark urine CT abdomen-normal Centrilobular bile stasis with lipofuscin pigment along
with collection of neutrophils within lobular parenchyma
Labs normalized by 6 months
Lee et al. [29] 2022 23 LGD-4033, RAD-140, YK11 12 7 Jaundice, scleral icterus,
decrease in appetite, and worsening pruritis
MRI and MRCP normal 0.8 Ursodeoxycholic
acid and hydroxyzine, labs normalized within a year
Peranathan et al. [30] 2022 30 RAD-140 Jaundice and fatigue Unspecified image normal Acute cholestasis with canalicular bile
plugs, without evidence of ductopenia
1.8 ursodeoxycholic acid and cholestyramine down-trending within 60–80 days
Peranathan et al. [30] 2022 43 RAD-140 Jaundice and fatigue Unspecified image normal Acute cholestasis with canalicular bile
plugs, without evidence of ductopenia
2.3 ursodeoxycholic acid and cholestyramine down-trending within 60–80 days
Weinblatt et al. [13] 2022 31 Enobosarm 2 0 Itch and dark-colored urine US abdomen, fatty liver, otherwise normal 7.5 Cyproheptadine, labs significantly improved after 7 days and normalized at 10 month follow up
Wallstab et al. [31] 2022 37 Ligandrol (LGD-4033) 4 mg 8 60 Jaundice, pruritus, anorexia, fatigue, 12 kg weight loss, dark urine U/S abdomen ruled out extrahepatic cholestasis and cholecystolithiasis
Fibroscan showed fibrosis 10.7 ± 2.3 kPa
Canalicular cholestasis, ductopenia,
Acute portal hepatitis with early periportal fibrosis
2.7 Ursodeoxycholic acid and cholestyramine, Linimentum Aquosum ointment