Figure 1.
Effect of Fc engineering on in vivo efficacy of anti-DENV antibody. AG129 mice were challenged with DENV-2, and 10 μg of the antibody, hIgG1 (blue), LALA (green), or LRGR (red) was administered two days after the virus challenge. The viremia was measured on day three (A) and day five (B) after the antibody injection. Each symbol represents one mouse and means ± SD are shown. Asterisks indicate statistical differences compared to a vehicle control group with Dunn’s multiple comparison test for the viremia on days three and five (**, p < 0.01; ***, p < 0.001). Survival analysis was conducted in this study (C). Asterisks indicate statistical differences compared to the vehicle control group with the Mantel-Cox test for the survival analysis (***, p < 0.001).