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Binding activity of Fc-engineered antibodies to human/mouse C1q. The binding activity of the anti-CD154 antibody, hIgG1 (blue), LALA (green), LRGR (red), or LALA/KAES (orange) to human C1q (A) or mouse C1q (B) was measured. The positions of the substitutions, LALA (green) and KAES (orange), are shown in the illustration of the hIgG1 Fc region (PDBID:3AVE) (C) and the sequence alignment (D). Figure 1C was generated with PyMOL.
