Table 1.
Characteristics of participants included in analysis of hepatitis type A and B, diphtheria, and tetanus with PFAS concentrations at age 28years.
| Characteristics | Hepatitis type A and B analyses |
Diphtheria and tetanus analyses |
||||||
|---|---|---|---|---|---|---|---|---|
| Total cohort (n = 399) | Male (n = 220, 55.1%) | Female (n = 179; 44.9%) | p-Valuea | Total cohort (n = 281 ) | Male (n = 133, 47.3%) | Female (n = 148, 52.7%) | p-Valuea | |
|
| ||||||||
| BMI, n (%) (kg/m2) | 0.47 | 0.05 | ||||||
| <18 | 1 (0.3) | 0 (0.0) | 1 (0.6) | 2 (0.7) | 0 (0.0) | 2 (1.4) | ||
| 18–25 | 182 (45.6) | 98 (44.5) | 84 (46.9) | 135 (48.0) | 56 (42.1) | 79 (53.4) | ||
| ≥25 | 216 (54.1) | 122 (55.5) | 94 (52.5) | 144 (51.2) | 77 (57.9) | 67 (45.3) | ||
| Smoking status, n (%) | 0.14 | 0.38 | ||||||
| Current | 206 (51.6) | 105 (47.7) | 101 (56.4) | 140 (49.8) | 72 (54.1) | 68 (45.9) | ||
| Ever | 52 (13.0) | 29 (13.2) | 23 (12.8) | 37 (13.2) | 15 (11.3) | 22 (14.9) | ||
| Never | 139 (34.8) | 86 (39.1) | 53 (29.6) | 103 (36.7) | 46 (34.6) | 57 (38.5) | ||
| Missing | 2 (0.5) | 0 (0.0) | 2 (1.1) | 1 (0.4) | 0 (0.0) | 1 (0.7) | ||
| Antibody concentrations, median (IQR) | ||||||||
| Baseline anti-diphtheria (IU/ mL) | - | - | - | 0.01 (0.05) | 0.01 (0.05) | 0.01 (0.05) | 0.23 | |
| Follow-up anti-diphtheria (IU/ mL) | - | - | - | 1.10 (2.92) | 1.60 (3.93) | 0.57 (2.10) | <0.001 | |
| Baseline anti-tetanus (IU/ mL) | - | - | - | 0.12 (0.52) | 0.12 (0.55) | 0.13 (0.52) | 0.61 | |
| Follow-up anti-tetanus (IU/ mL) | - | - | - | 6.60 (12.80) | 7.50 (13.8) | 5.65 (8.10) | 0.03 | |
| Follow-up anti-FIAV (S/CO) | 6.11 (4.00) | 5.61 (3.78) | 6.85 (3.73) | 0.002 | - | - | - | |
| Follow-up anti-FIBs (mlU/mL) | 56.5 (143.60) | 66.76 (159.48) | 44.28 (113.96) | 0.006 | - | - | - | |
a
Chi-square test for BMI and smoking status and Wilcoxon rank-sum test for antibody and PFAS concentrations.
b
IQR: interquartile range; S/CO: signal-to-cutoff ratio; PFAS: per- and polyfluoroalkyl substance; PFOS: perfluorooctane sulfonate; PFOA: perflourooctanoate; PFHxS: perfluorohexanesulfonic acid; PFNA: perfluoronona-noate; PFDA: perfluorodecanoate.