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. 2023 Apr 6;61(5):e00014-23. doi: 10.1128/jcm.00014-23

FIG 4.

FIG 4

Genomic analyses identify NICU MLST 1535 strains with international clusters similar resistance gene profiles and variant SCCmecs. A SNP-based phylogeny of the 25 closest related strains to cluster 5, produced the same as Fig. 3. (A) Strains outside the MLST 1535 box are MLST 15. Antibiotic resistance gene profiles show the stepwise acquisition and loss of resistance genes (B). A high-resolution genomic map of the SCCmec region from NCBI cluster 5 isolates closed by long-read genome sequencing (C). Gradients in the IS element keys show directionality of the similar sequences. A 13 base AAACTAAAAAAT core sequence (DR1 TO DR3) with variable adjacent homologous sequence is directly repeated (DR) three times. This sequence does not appear elsewhere in the genome.